Results
| PMID | 8423963 |
| Gene Name | PAFAH1B2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 20 |
| Population details | 20 (8 fertile women without endometriosis, 12 women with mild endometriosis) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
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Obstet Gynecol. 1993 Feb;81(2):276-9. Hemmings, R| Miron, P| Falcone, T| Bourque, J| Lepage, N| Langlais, J Institut de Medecine de la Reproduction de Montreal, Quebec, Canada. OBJECTIVE: To investigate whether platelet-activating factor acetylhydrolase may play a role in the pathophysiology of endometriosis. METHODS: Peritoneal fluids were obtained at laparoscopy from eight fertile women without endometriosis and 12 women with mild endometriosis. Platelet-activating factor acetylhydrolase activity was assayed in serum and peritoneal fluid by the release of 3H-acetate from [3H]-platelet-activating factor during a 15-minute incubation. RESULTS: Platelet-activating factor acetylhydrolase activity (mean +/- standard error of the mean) was significantly lower (P < .01) in peritoneal fluids from women with mild endometriosis (29.5 +/- 2.7%) than in controls (39.9 +/- 3.4%). The platelet-activating factor acetylhydrolase-cholesterol and -albumin ratios were also significantly lower in peritoneal fluids of women with endometriosis compared with controls (P < .006 and P < .012, respectively). CONCLUSION: These data suggest that mild endometriosis is associated with decreased platelet-activating factor acetylhydrolase activity in peritoneal fluid. Mesh Terms: 1-Alkyl-2-acetylglycerophosphocholine Esterase| Adult| Albumins/analysis| Ascitic Fluid/chemistry/*enzymology| Cholesterol/analysis| Endometriosis/*enzymology/metabolism| Female| Humans| Phospholipases A/*metabolism| Platelet Activating Factor/*m |
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